// Copyright 2014 The Rust Project Developers. See the COPYRIGHT // file at the top-level directory of this distribution and at // http://rust-lang.org/COPYRIGHT. // // Licensed under the Apache License, Version 2.0 or the MIT license // , at your // option. This file may not be copied, modified, or distributed // except according to those terms. use std::cmp::min; use std::io::{stdout, IoResult}; use std::os; use std::slice::bytes::copy_memory; use std::slice; static LINE_LEN: uint = 60; static LOOKUP_SIZE: uint = 4 * 1024; static LOOKUP_SCALE: f32 = (LOOKUP_SIZE - 1) as f32; // Random number generator constants static IM: u32 = 139968; static IA: u32 = 3877; static IC: u32 = 29573; static ALU: &'static str = "GGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTG\ GGAGGCCGAGGCGGGCGGATCACCTGAGGTCAGGAGTTCGA\ GACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAA\ AATACAAAAATTAGCCGGGCGTGGTGGCGCGCGCCTGTAAT\ CCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAAC\ CCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCACTG\ CACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAA"; static NULL_AMINO_ACID: AminoAcid = AminoAcid { c: ' ' as u8, p: 0.0 }; static IUB: [AminoAcid, ..15] = [ AminoAcid { c: 'a' as u8, p: 0.27 }, AminoAcid { c: 'c' as u8, p: 0.12 }, AminoAcid { c: 'g' as u8, p: 0.12 }, AminoAcid { c: 't' as u8, p: 0.27 }, AminoAcid { c: 'B' as u8, p: 0.02 }, AminoAcid { c: 'D' as u8, p: 0.02 }, AminoAcid { c: 'H' as u8, p: 0.02 }, AminoAcid { c: 'K' as u8, p: 0.02 }, AminoAcid { c: 'M' as u8, p: 0.02 }, AminoAcid { c: 'N' as u8, p: 0.02 }, AminoAcid { c: 'R' as u8, p: 0.02 }, AminoAcid { c: 'S' as u8, p: 0.02 }, AminoAcid { c: 'V' as u8, p: 0.02 }, AminoAcid { c: 'W' as u8, p: 0.02 }, AminoAcid { c: 'Y' as u8, p: 0.02 }, ]; static HOMO_SAPIENS: [AminoAcid, ..4] = [ AminoAcid { c: 'a' as u8, p: 0.3029549426680 }, AminoAcid { c: 'c' as u8, p: 0.1979883004921 }, AminoAcid { c: 'g' as u8, p: 0.1975473066391 }, AminoAcid { c: 't' as u8, p: 0.3015094502008 }, ]; // FIXME: Use map(). fn sum_and_scale(a: &'static [AminoAcid]) -> Vec { let mut result = Vec::new(); let mut p = 0f32; for a_i in a.iter() { let mut a_i = *a_i; p += a_i.p; a_i.p = p * LOOKUP_SCALE; result.push(a_i); } let result_len = result.len(); result.get_mut(result_len - 1).p = LOOKUP_SCALE; result } struct AminoAcid { c: u8, p: f32, } struct RepeatFasta<'a, W> { alu: &'static str, out: &'a mut W } impl<'a, W: Writer> RepeatFasta<'a, W> { fn new(alu: &'static str, w: &'a mut W) -> RepeatFasta<'a, W> { RepeatFasta { alu: alu, out: w } } fn make(&mut self, n: uint) -> IoResult<()> { let alu_len = self.alu.len(); let mut buf = slice::from_elem(alu_len + LINE_LEN, 0u8); let alu: &[u8] = self.alu.as_bytes(); copy_memory(buf, alu); let buf_len = buf.len(); copy_memory(buf.mut_slice(alu_len, buf_len), alu.slice_to(LINE_LEN)); let mut pos = 0; let mut bytes; let mut n = n; while n > 0 { bytes = min(LINE_LEN, n); try!(self.out.write(buf.slice(pos, pos + bytes))); try!(self.out.write_u8('\n' as u8)); pos += bytes; if pos > alu_len { pos -= alu_len; } n -= bytes; } Ok(()) } } fn make_lookup(a: &[AminoAcid]) -> [AminoAcid, ..LOOKUP_SIZE] { let mut lookup = [ NULL_AMINO_ACID, ..LOOKUP_SIZE ]; let mut j = 0; for (i, slot) in lookup.mut_iter().enumerate() { while a[j].p < (i as f32) { j += 1; } *slot = a[j]; } lookup } struct RandomFasta<'a, W> { seed: u32, lookup: [AminoAcid, ..LOOKUP_SIZE], out: &'a mut W, } impl<'a, W: Writer> RandomFasta<'a, W> { fn new(w: &'a mut W, a: &[AminoAcid]) -> RandomFasta<'a, W> { RandomFasta { seed: 42, out: w, lookup: make_lookup(a), } } fn rng(&mut self, max: f32) -> f32 { self.seed = (self.seed * IA + IC) % IM; max * (self.seed as f32) / (IM as f32) } fn nextc(&mut self) -> u8 { let r = self.rng(1.0); for a in self.lookup.iter() { if a.p >= r { return a.c; } } 0 } fn make(&mut self, n: uint) -> IoResult<()> { let lines = n / LINE_LEN; let chars_left = n % LINE_LEN; let mut buf = [0, ..LINE_LEN + 1]; for _ in range(0, lines) { for i in range(0u, LINE_LEN) { buf[i] = self.nextc(); } buf[LINE_LEN] = '\n' as u8; try!(self.out.write(buf)); } for i in range(0u, chars_left) { buf[i] = self.nextc(); } self.out.write(buf.slice_to(chars_left)) } } fn main() { let args = os::args(); let n = if args.len() > 1 { from_str::(args[1]).unwrap() } else { 5 }; let mut out = stdout(); out.write_line(">ONE Homo sapiens alu").unwrap(); { let mut repeat = RepeatFasta::new(ALU, &mut out); repeat.make(n * 2).unwrap(); } out.write_line(">TWO IUB ambiguity codes").unwrap(); let iub = sum_and_scale(IUB); let mut random = RandomFasta::new(&mut out, iub.as_slice()); random.make(n * 3).unwrap(); random.out.write_line(">THREE Homo sapiens frequency").unwrap(); let homo_sapiens = sum_and_scale(HOMO_SAPIENS); random.lookup = make_lookup(homo_sapiens.as_slice()); random.make(n * 5).unwrap(); random.out.write_str("\n").unwrap(); }