diff --git a/compiler/rustc_ty_utils/src/abi.rs b/compiler/rustc_ty_utils/src/abi.rs
index 442d041a8a7..9b0d34b8979 100644
--- a/compiler/rustc_ty_utils/src/abi.rs
+++ b/compiler/rustc_ty_utils/src/abi.rs
@@ -238,6 +238,7 @@ fn adjust_for_rust_scalar<'tcx>(
     layout: TyAndLayout<'tcx>,
     offset: Size,
     is_return: bool,
+    is_drop_target: bool,
 ) {
     // Booleans are always a noundef i1 that needs to be zero-extended.
     if scalar.is_bool() {
@@ -307,6 +308,25 @@ fn adjust_for_rust_scalar<'tcx>(
             }
         }
     }
+
+    // If this is the argument to `drop_in_place`, the contents of which we fully control as the
+    // compiler, then we may be able to mark that argument `noalias`. Currently, we're conservative
+    // and do so only if `drop_in_place` results in a direct call to the programmer's `drop` method.
+    // The `drop` method requires `&mut self`, so we're effectively just propagating the `noalias`
+    // guarantee from `drop` upward to `drop_in_place` in this case.
+    if is_drop_target {
+        match *layout.ty.kind() {
+            ty::RawPtr(inner) => {
+                if let ty::Adt(adt_def, _) = inner.ty.kind() {
+                    if adt_def.destructor(cx.tcx()).is_some() {
+                        debug!("marking drop_in_place argument as noalias");
+                        attrs.set(ArgAttribute::NoAlias);
+                    }
+                }
+            }
+            _ => bug!("drop target isn't a raw pointer"),
+        }
+    }
 }
 
 // FIXME(eddyb) perhaps group the signature/type-containing (or all of them?)
@@ -362,10 +382,16 @@ fn fn_abi_new_uncached<'tcx>(
     use SpecAbi::*;
     let rust_abi = matches!(sig.abi, RustIntrinsic | PlatformIntrinsic | Rust | RustCall);
 
+    let is_drop_in_place = match (cx.tcx.lang_items().drop_in_place_fn(), fn_def_id) {
+        (Some(drop_in_place_fn), Some(fn_def_id)) => drop_in_place_fn == fn_def_id,
+        _ => false,
+    };
+
     let arg_of = |ty: Ty<'tcx>, arg_idx: Option<usize>| -> Result<_, FnAbiError<'tcx>> {
         let span = tracing::debug_span!("arg_of");
         let _entered = span.enter();
         let is_return = arg_idx.is_none();
+        let is_drop_target = is_drop_in_place && arg_idx == Some(0);
 
         let layout = cx.layout_of(ty)?;
         let layout = if force_thin_self_ptr && arg_idx == Some(0) {
@@ -379,7 +405,15 @@ fn fn_abi_new_uncached<'tcx>(
 
         let mut arg = ArgAbi::new(cx, layout, |layout, scalar, offset| {
             let mut attrs = ArgAttributes::new();
-            adjust_for_rust_scalar(*cx, &mut attrs, scalar, *layout, offset, is_return);
+            adjust_for_rust_scalar(
+                *cx,
+                &mut attrs,
+                scalar,
+                *layout,
+                offset,
+                is_return,
+                is_drop_target,
+            );
             attrs
         });
 
diff --git a/tests/codegen/drop-in-place-noalias.rs b/tests/codegen/drop-in-place-noalias.rs
new file mode 100644
index 00000000000..bd9de4ad972
--- /dev/null
+++ b/tests/codegen/drop-in-place-noalias.rs
@@ -0,0 +1,34 @@
+// Tests that the compiler can mark `drop_in_place` as `noalias` when safe to do so.
+
+#![crate_type="lib"]
+
+use std::hint::black_box;
+
+// CHECK: define{{.*}}drop_in_place{{.*}}Foo{{.*}}({{.*}}noalias{{.*}})
+
+#[repr(C)]
+pub struct Foo {
+    a: i32,
+    b: i32,
+    c: i32,
+}
+
+impl Drop for Foo {
+    #[inline(never)]
+    fn drop(&mut self) {
+        black_box(self.a);
+    }
+}
+
+extern {
+    fn bar();
+    fn baz(foo: Foo);
+}
+
+pub fn haha() {
+    let foo = Foo { a: 1, b: 2, c: 3 };
+    unsafe {
+        bar();
+        baz(foo);
+    }
+}