diff --git a/src/tools/tidy/src/allowed_run_make_makefiles.txt b/src/tools/tidy/src/allowed_run_make_makefiles.txt
index 118e76fdbcd..559782056e6 100644
--- a/src/tools/tidy/src/allowed_run_make_makefiles.txt
+++ b/src/tools/tidy/src/allowed_run_make_makefiles.txt
@@ -158,7 +158,6 @@ run-make/target-without-atomic-cas/Makefile
 run-make/test-benches/Makefile
 run-make/thumb-none-cortex-m/Makefile
 run-make/thumb-none-qemu/Makefile
-run-make/track-pgo-dep-info/Makefile
 run-make/translation/Makefile
 run-make/type-mismatch-same-crate-name/Makefile
 run-make/unstable-flag-required/Makefile
diff --git a/tests/run-make/proc-macro-three-crates/rmake.rs b/tests/run-make/proc-macro-three-crates/rmake.rs
index 62dc547fcfb..d3735540fdd 100644
--- a/tests/run-make/proc-macro-three-crates/rmake.rs
+++ b/tests/run-make/proc-macro-three-crates/rmake.rs
@@ -5,8 +5,6 @@
 // This was fixed in #37846, and this test checks
 // that this bug does not make a resurgence.
 
-//FIXME(Oneirical): ignore-cross-compile
-
 use run_make_support::{bare_rustc, cwd, rust_lib_name, rustc};
 
 fn main() {
diff --git a/tests/run-make/track-path-dep-info/rmake.rs b/tests/run-make/track-path-dep-info/rmake.rs
index f4a77c7fc21..f108dc66051 100644
--- a/tests/run-make/track-path-dep-info/rmake.rs
+++ b/tests/run-make/track-path-dep-info/rmake.rs
@@ -4,12 +4,10 @@
 // output successfully added the file as a dependency.
 // See https://github.com/rust-lang/rust/pull/84029
 
-//FIXME(Oneirical): Try it on musl
-
-use run_make_support::{bare_rustc, fs_wrapper, rustc};
+use run_make_support::{fs_wrapper, rustc};
 
 fn main() {
-    bare_rustc().input("macro_def.rs").run();
+    rustc().input("macro_def.rs").run();
     rustc().env("EXISTING_PROC_MACRO_ENV", "1").emit("dep-info").input("macro_use.rs").run();
     assert!(fs_wrapper::read_to_string("macro_use.d").contains("emojis.txt:"));
 }
diff --git a/tests/run-make/track-pgo-dep-info/Makefile b/tests/run-make/track-pgo-dep-info/Makefile
deleted file mode 100644
index 3afe3662fa7..00000000000
--- a/tests/run-make/track-pgo-dep-info/Makefile
+++ /dev/null
@@ -1,25 +0,0 @@
-# needs-profiler-support
-
-include ../tools.mk
-
-# FIXME(eddyb) provide `HOST_RUSTC` and `TARGET_RUSTC`
-# instead of hardcoding them everywhere they're needed.
-ifeq ($(IS_MUSL_HOST),1)
-ADDITIONAL_ARGS := $(RUSTFLAGS)
-endif
-
-all:
-	# Generate PGO profiles
-	$(BARE_RUSTC) $(ADDITIONAL_ARGS) -Cprofile-generate=$(TMPDIR)/profiles --out-dir $(TMPDIR) main.rs
-	$(TMPDIR)/main
-
-	# Merge profiles
-	"$(LLVM_BIN_DIR)/llvm-profdata" merge \
-		-o "$(TMPDIR)/merged.profdata" \
-		"$(TMPDIR)/profiles" || exit 1
-
-	# Use the profile
-	$(RUSTC) -Cprofile-use=$(TMPDIR)/merged.profdata --emit dep-info main.rs
-
-	# Check that profile file is in depinfo
-	$(CGREP) "merged.profdata" < $(TMPDIR)/main.d
diff --git a/tests/run-make/track-pgo-dep-info/rmake.rs b/tests/run-make/track-pgo-dep-info/rmake.rs
new file mode 100644
index 00000000000..acfe05cf8ea
--- /dev/null
+++ b/tests/run-make/track-pgo-dep-info/rmake.rs
@@ -0,0 +1,23 @@
+// Emitting dep-info files used to not have any mention of PGO profiles used
+// in compilation, which meant these profiles could be changed without consequence.
+// After changing this in #100801, this test checks that the profile data is successfully
+// included in dep-info emit files.
+// See https://github.com/rust-lang/rust/pull/100801
+
+//@ ignore-cross-compile
+// Reason: the binary is executed
+//@ needs-profiler-support
+
+use run_make_support::{fs_wrapper, llvm_profdata, run, rustc};
+
+fn main() {
+    // Generate the profile-guided-optimization (PGO) profiles
+    rustc().profile_generate("profiles").input("main.rs").run();
+    // Merge the profiles
+    run("main");
+    llvm_profdata().merge().output("merged.profdata").input("profiles").run();
+    // Use the profiles in compilation
+    rustc().profile_use("merged.profdata").emit("dep-info").input("main.rs").run();
+    // Check that the profile file is in the dep-info emit file
+    assert!(fs_wrapper::read_to_string("main.d").contains("merged.profdata"));
+}