diff --git a/library/std/src/os/linux/fs.rs b/library/std/src/os/linux/fs.rs
index 479bbcc17a8..ab0b2a3eda3 100644
--- a/library/std/src/os/linux/fs.rs
+++ b/library/std/src/os/linux/fs.rs
@@ -329,7 +329,14 @@ pub trait MetadataExt {
 impl MetadataExt for Metadata {
     #[allow(deprecated)]
     fn as_raw_stat(&self) -> &raw::stat {
-        unsafe { &*(self.as_inner().as_inner() as *const libc::stat64 as *const raw::stat) }
+        #[cfg(target_env = "musl")]
+        unsafe {
+            &*(self.as_inner().as_inner() as *const libc::stat as *const raw::stat)
+        }
+        #[cfg(not(target_env = "musl"))]
+        unsafe {
+            &*(self.as_inner().as_inner() as *const libc::stat64 as *const raw::stat)
+        }
     }
     fn st_dev(&self) -> u64 {
         self.as_inner().as_inner().st_dev as u64
diff --git a/library/std/src/sys/unix/fd.rs b/library/std/src/sys/unix/fd.rs
index 6c4f408426a..bf1fb3123c4 100644
--- a/library/std/src/sys/unix/fd.rs
+++ b/library/std/src/sys/unix/fd.rs
@@ -126,9 +126,17 @@ pub fn read_to_end(&self, buf: &mut Vec<u8>) -> io::Result<usize> {
     }
 
     pub fn read_at(&self, buf: &mut [u8], offset: u64) -> io::Result<usize> {
-        #[cfg(not(any(target_os = "linux", target_os = "android", target_os = "hurd")))]
+        #[cfg(not(any(
+            all(target_os = "linux", not(target_env = "musl")),
+            target_os = "android",
+            target_os = "hurd"
+        )))]
         use libc::pread as pread64;
-        #[cfg(any(target_os = "linux", target_os = "android", target_os = "hurd"))]
+        #[cfg(any(
+            all(target_os = "linux", not(target_env = "musl")),
+            target_os = "android",
+            target_os = "hurd"
+        ))]
         use libc::pread64;
 
         unsafe {
@@ -285,9 +293,17 @@ pub fn is_write_vectored(&self) -> bool {
     }
 
     pub fn write_at(&self, buf: &[u8], offset: u64) -> io::Result<usize> {
-        #[cfg(not(any(target_os = "linux", target_os = "android", target_os = "hurd")))]
+        #[cfg(not(any(
+            all(target_os = "linux", not(target_env = "musl")),
+            target_os = "android",
+            target_os = "hurd"
+        )))]
         use libc::pwrite as pwrite64;
-        #[cfg(any(target_os = "linux", target_os = "android", target_os = "hurd"))]
+        #[cfg(any(
+            all(target_os = "linux", not(target_env = "musl")),
+            target_os = "android",
+            target_os = "hurd"
+        ))]
         use libc::pwrite64;
 
         unsafe {
diff --git a/library/std/src/sys/unix/fs.rs b/library/std/src/sys/unix/fs.rs
index e1c58f2ba3c..40eb910fdc3 100644
--- a/library/std/src/sys/unix/fs.rs
+++ b/library/std/src/sys/unix/fs.rs
@@ -40,13 +40,17 @@
 ))]
 use libc::c_char;
 #[cfg(any(
-    target_os = "linux",
+    all(target_os = "linux", not(target_env = "musl")),
     target_os = "emscripten",
     target_os = "android",
-    target_os = "hurd",
+    target_os = "hurd"
 ))]
 use libc::dirfd;
-#[cfg(any(target_os = "linux", target_os = "emscripten", target_os = "hurd"))]
+#[cfg(any(
+    all(target_os = "linux", not(target_env = "musl")),
+    target_os = "emscripten",
+    target_os = "hurd"
+))]
 use libc::fstatat64;
 #[cfg(any(
     target_os = "android",
@@ -57,9 +61,10 @@
     target_os = "aix",
     target_os = "nto",
     target_os = "vita",
+    all(target_os = "linux", target_env = "musl"),
 ))]
 use libc::readdir as readdir64;
-#[cfg(any(target_os = "linux", target_os = "hurd"))]
+#[cfg(any(all(target_os = "linux", not(target_env = "musl")), target_os = "hurd"))]
 use libc::readdir64;
 #[cfg(any(target_os = "emscripten", target_os = "l4re"))]
 use libc::readdir64_r;
@@ -84,7 +89,7 @@
     lstat as lstat64, off64_t, open as open64, stat as stat64,
 };
 #[cfg(not(any(
-    target_os = "linux",
+    all(target_os = "linux", not(target_env = "musl")),
     target_os = "emscripten",
     target_os = "l4re",
     target_os = "android",
@@ -95,7 +100,7 @@
     lstat as lstat64, off_t as off64_t, open as open64, stat as stat64,
 };
 #[cfg(any(
-    target_os = "linux",
+    all(target_os = "linux", not(target_env = "musl")),
     target_os = "emscripten",
     target_os = "l4re",
     target_os = "hurd"
@@ -853,10 +858,10 @@ pub fn file_name(&self) -> OsString {
 
     #[cfg(all(
         any(
-            target_os = "linux",
+            all(target_os = "linux", not(target_env = "musl")),
             target_os = "emscripten",
             target_os = "android",
-            target_os = "hurd",
+            target_os = "hurd"
         ),
         not(miri)
     ))]
@@ -882,7 +887,7 @@ pub fn metadata(&self) -> io::Result<FileAttr> {
 
     #[cfg(any(
         not(any(
-            target_os = "linux",
+            all(target_os = "linux", not(target_env = "musl")),
             target_os = "emscripten",
             target_os = "android",
             target_os = "hurd",