diff --git a/compiler/rustc_typeck/src/check/upvar.rs b/compiler/rustc_typeck/src/check/upvar.rs
index 0482e8b895b..428a866c1fe 100644
--- a/compiler/rustc_typeck/src/check/upvar.rs
+++ b/compiler/rustc_typeck/src/check/upvar.rs
@@ -1648,7 +1648,8 @@ fn restrict_repr_packed_field_ref_capture<'tcx>(
         match p.kind {
             ProjectionKind::Field(..) => match ty.kind() {
                 ty::Adt(def, _) if def.repr.packed() => {
-                    match tcx.layout_of(param_env.and(p.ty)) {
+                    // We erase regions here because they cannot be hashed
+                    match tcx.layout_of(param_env.and(tcx.erase_regions(p.ty))) {
                         Ok(layout) if layout.align.abi.bytes() == 1 => {
                             // if the alignment is 1, the type can't be further
                             // disaligned.